Glucose 6-Phosphate Dehydrogenase Deficiency

Exploration of Metabolic Dis coif: Glucose 6-phosphate dehydrogenase compulsion 1.0 Abstract Glucose 6-phosphate dehydrogenase deficiency, with over cd million cases, is the most prevalent enzyme defect worldwide. higher(prenominal) frequencies argon recorded in Africa, Asia and the Mediterranean. It has also been observed that up to decennary per cent of Afri arsehole American males have a return form of this deficiency. This distemper is caused by X cerebrate inherited mutation in the glucose 6-phosphate dehydrogenase gene resulting in light amounts of the enzyme glucose 6-phosphate dehydrogenase creation produced. This enzyme is involved in the production of NADPH for loss line fling cells by way of the pentose phosphate pathway and increases the antioxidant status of leave alone tongue to tissues. A deficiency in the enzyme results in the oxidation of red blood cell membranes leading to decrementd lifespan of the cell and associated disease s such as haemolytic anaemia, neonatal sour and kernicterus. The deficiency is most commonly asymptomatic but can be diagnosed according to the manifestations of the disease.

The causes of manifestations of this disease includes: The consumption of fava beans (which contain glycosides and phagocytosing granulocytes), acute bacterial or viral infections and medications such as Primaquine, phenazopyridine and methylene blue. Treatment is limited and thus prevention activities moldiness be undertaken to avoid manifestations. Avoidance of foods and medications containing agents likely to increase oxidation activities is necessary. This disease is rarely fatal ! but can lead to persistent impairment and thus must be prevented and monitored. future areas for developing regarding this area should be in the development of an handy application tool for populations at risk. This could lead to a decrease in frequency of clinical manifestations of this disease. 2.0 Introduction With over 400 million diagnosed cases of Glucose 6-phosphate dehydrogenase (G6PD)...If you want to get a full essay, order it on our website: BestEssayCheap.com

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